1. What information does TM-MC 2.0 hold?: TM-MC 2.0 provides information on the chemical compounds of medicinal materials listed in the Korean, Chinese, and Japanese pharmacopoeias. TM-MC 2.0 also includes new information on prescriptions, gene targets, modern diseases, and their associations.

2. How was TM-MC 2.0 constructed?: (1) PubMed articles were searched using the names of medicinal materials listed in the Korean, Chinese, and Japanese pharmacopoeias, and chromatographic articles were filtered with the following words: “chromatograph”, “CCC”, “CEC”, “CMC”, “FPLC”, “GC/MS”, “GC-MS”, “GLC”, “GPC”, “HPLC”, “IMAC”, “LC/MS”, “LC-MS”, “MEEKC”, “MEKC”, “NPLC”, “PGC”, “RPC”, “RPLC”, “RSLC”, “SEC”, “SFC”, “SMBC”, “TLC”, “TMBC”, “UFLC”, and “UPLC”. Then, Korean medicine experts manually extracted the names of the constituent compounds of medicinal materials from the full text of the filtered articles.
(2) All compound names have been identified and de-duplicated, and are given with their corresponding identifiers and pharmacokinetic properties.
(3) Information on targets of chemical compounds and diseases related to the targets was retrieved from STITCH v5.0 and DisGeNET v7.0, respectively.
(4) Prescriptions containing medicinal materials were extracted and curated manually from prescription textbooks and internal medicine textbooks used at Korean medicine universities.

3. How does TM-MC 2.0 differ from other TCM databases?: TM-MC 2.0 has an advantage in that it contains the largest number of identified chemical data of medicinal materials listed in Chinese pharmacopoeia compared to other TCM databases. In recent years, many chromatographic articles have been published on the chemical compounds of medicinal materials in PubMed. Through manual curation of these articles, TM-MC 2.0 contains many new compounds that do not exist in other TCM databases.
Moreover, TM-MC 2.0 includes the largest number of marker compounds listed in the Chinese pharmacopoeia compared to TCMSP 2.3 and TCMID 2.0. This indicates that TM-MC 2.0 provides better information than other TCM databases on the quantity and quality about the chemical compounds of medicinal materials.

4. How can I obtain information on TM-MC 2.0?: All data is listed in the “Browse” menu on TM-MC 2.0 website.
All data can be downloaded as excel files in the "Download" menu on TM-MC 2.0 website.

5. How can I search for information on TM-MC 2.0?

1. Browse (All data is listed on separate tabs)

(1) Users can browse all medicinal materials by clicking the "Browse" menu on TM-MC website.
(2) Other data, such as compounds and prescriptions, is separated by tabs and users can browse them by selecting the corresponding tabs.
(3) All data is sorted in an ascending order by latin name in medicinal materials, compound name in compounds, protein name in targets, disease name in diseases, and Korean and textbook in prescriptions.
(4) Click on a row to see more information. The detailed information is described in section 3 below.

2. Keyword search

(1) Users can search for TM-MC data by clicking the "Search" menu on TM-MC website.
(2) All data can be searched in one search field. Search keywords must be at least two characters long. Search results are shown separated by tabs and the number on the tabs is the number of search results.
(3) Search examples are listed for users who do not know which search terms to use. When you click on a search example, a search is performed using the keyword you clicked. The detailed information is described in section 3 below.

3. Detailed information

Medicinal material

If you type "ginseng" into the search field, five medicinal materials with "ginseng" in their names are searched. If you click on "Ginseng Radix", the details about the medicinal material are shown.

(1) Representative names of the medicinal material.
(2) Names and scientific names of the medicinal material in Korean, Chinese, and Japanese pharmacopeias.
(3) Traditional usages and modern treatments of the medicinal material. These have been extracted and curated from the linked reference article.
(4) Pictures of the medicinal material.
(5) Prescriptions containing the medicinal material. This information is shown in a separate page due to its large number.
(6) Constituent compounds of the medicinal material. The compound name is the name as written in the paper. Same compounds with different names are given the same TM-MC ID. Moreover, it is provided that links to the PubChem compounds that maps to the InChIKey of TM-MC ID and links to the PubMed articles from which the compound was extracted.

Compound

If you type "glycyrrhizic acid" into the search field, five compounds with "glycyrrhizic acid" in their names are searched. If you click on "glycyrrhizic acid", the details about the compound are shown.
Note that this result is for ingredient 14982, not just for glycyrrhizic acid.

(1) A compound name of TM-MC ID 14982.
(2) Chemical structure of TM-MC ID 14982 that was identified in TM-MC.
(3) Download links of a JPG file and a SDF file for TM-MC ID 14982.
(4) Creation and modification dates for TM-MC ID 14982.
(5) List of compounds with TM-MC ID 14982 in TM-MC.
(6) PubChem Compound ID with the same InChIKey as the InChIKey of TM-MC ID 14982.
(7) InChIKey for TM-MC ID 14982.
(8) SMILES string for TM-MC ID 14982.
(9) Molecular formula for TM-MC ID 14982.
(10) Pharmacokinetic properties for TM-MC ID 14982.
(11) List of medicinal materials with TM-MC ID 14982 as a constituent compound.
(12) List of target proteins in STITCH v5.0 database that map to TM-MC ID 14982.

Protein

If you type "tgfb1" into the search field, two targets with "tgfb1" in their names are searched. If you click on "TGFB1", the details about the protein are shown.

(1) Protein ID, size, and annotation that are provided in STITCH v5.0.
(2) List of compounds in TM-MC 2.0 that map to TGFB1.
(3) List of diseases in DisGeNET v7.0 that map to TGFB1.

Disease

If you type "essential hypertension" into the search field, four diseases with "essential hypertension" in their names are searched. If you click on "Essential Hypertension", the details about the disease are shown.

(1) Disease ID, type, and class that are provided in DisGeNET v7.0.
(2) List of proteins in STITCH v5.0 that map to disease ID C0085580.

Prescription

If you type "yungmijihwanghwan" into the search field, eight prescriptions with "yungmijihwanghwan" in their names are searched. If you click on second "Yungmijihwanghwan", the details about the prescription are shown.

(1) Names of Yungmijihwanghwan prescription.
(2) Referenced ancient literature of the prescription.
(3) Textbook and page number from which the prescription was extracted.
(4) Indications and the corresponding PubMed IDs about the prescription described in the PubMed articles.
(5) Medicinal materials and their corresponding processing methods and dosages in the prescription.