ephedrine
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Create 2016-06-08
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TM-MC Compound ID 9294
TM-MC Compound Synonyms (-)-ephedrine; L-ephedrine; L-(-)-ephedrine; (1R,2S)-ephedrine
PubChem Compound ID 9294
InChI 1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
InChIKey KWGRBVOPPLSCSI-WPRPVWTQSA-N
SMILES CN[C@@H](C)[C@H](O)c1ccccc1
Molecular Formula C10H15NO
Molecular Weight 165.236 Exact Molecular Weight 165.115364107
LogP 1.318 Topological Polar Surface Area 32.26 Ų
Atom Count 27 Structural Alert Count 0
Hydrogen Bond Acceptor Count 2 Hydrogen Bond Donor Count 2
Rotatable Bond Count 3 Aromatic Ring Count 1
Drug Likeness 0.71 Oral Bioavailability Y
Related Medicinal Materials (6 results)
No Latin Korean Chinese Japanese PubMed link
6 Ephedrae Herba 마황 麻黄 マオウ [1][2][3][4][5][6][7][8][9][10]
[11][12][13][14][15][16][17][18][19][20]
[21][22][23]
5 Ephedrae Radix 마황근 麻黄根 [1]
4 Ipecacuanhae Radix et Rhizoma 토근 吐根 トコン [1]
3 Pinelliae Rhizoma Praeparatum Cum Zingibere et Alumine 강반하 薑半夏 [1]
2 Pinelliae Tuber 반하 半夏 ハンゲ [1][2]
1 Thymi Herba 사향초 麝香草 [1]
Related Proteins (148 results) (STITCH)
No Protein ID Protein name Annotation Score String DB link
148 ENSP00000232892 AADAC Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. 0.151 Link
147 ENSP00000348911 AADACL2 Arylacetamide deacetylase like 2. 0.151 Link
146 ENSP00000352268 AADACL3 Arylacetamide deacetylase like 3; Belongs to the 'GDXG' lipolytic enzyme family. 0.151 Link
145 ENSP00000365395 AADACL4 Arylacetamide deacetylase like 4. 0.151 Link
144 ENSP00000290866 ACE Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety; Belongs to the peptidase M2 family. 0.168 Link
143 ENSP00000303211 ACHE Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. 0.884 Link
142 ENSP00000369960 ADRA1A Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. 0.82 Link
141 ENSP00000306662 ADRA1B Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily. 0.17 Link
140 ENSP00000368766 ADRA1D Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily. 0.17 Link
139 ENSP00000280155 ADRA2A Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p- octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. 0.817 Link
Related Proteins (42 results) (PubChem)
No Protein ID Protein name Annotation String DB link
42 ENSP00000303909 ABR Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] Link
41 ENSP00000357873 ACADSB Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent. Link
40 ENSP00000303211 ACHE Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs to the type-B carboxylesterase/lipase family. Link
39 ENSP00000224784 ACTA2 Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Link
38 ENSP00000369960 ADRA1A Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. Link
37 ENSP00000306662 ADRA1B Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily. Link
36 ENSP00000368766 ADRA1D Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily. Link
35 ENSP00000280155 ADRA2A Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p- octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Link
34 ENSP00000480573 ADRA2B Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. [...] Link
33 ENSP00000386069 ADRA2C Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily. Link